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�Fy�� Ethanol is highly toxic to all GI tract cells. 0000007673 00000 n
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It is primarily used as a chemical intermediate, principally for the production of acetic acid, pyridine and pyridine bases, peracetic acid, pentaeythritol, butylene glycol, and chloral. 0000003092 00000 n
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Indeed, ethanol-induced excitation of posterior VTA dopamine cells in a midbrain slice preparation appears to require ethanol’s first metabolite (i.e. 0000002541 00000 n
Here are some of the effects of acetaldehyde (significantly more toxic than ethanol): Is responsible for most of the symptoms of a hangover. 0000001354 00000 n
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Normally, acetaldehyde is quickly broken down, but in those with ALDH2 Deficiency, acetaldehyde accumulates to very high concentrations (more than 10x of an individual with normal ALDH2). 0000000016 00000 n
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At these concentrations, acetaldehyde causes Alcohol Flush Reaction. 0000004953 00000 n
Under normal physiological conditions, ethanol is metabolized to acetaldehyde (ACA) through several enzymatic pathways involving alcohol dehydrogenase (ADH), cytochrome P4502E1 (CYP2E1), or catalase. NADH is the reducing agent NADH and ethanol are the reduced forms n�_�ch=>�U�[~#:���6-M�G� �qԞm4ڝF[�c�NG`�/# :CTB�"����Pq}�R�C��0��t�Y�n Acetaldehyde Production by Ethanol Dehydrogenation Background Acetaldehyde is a colorless liquid with a pungent, fruity odor. 0000005607 00000 n
Ethanol is broken down into acetaldehyde during alcohol metabolism. 337 24
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acetaldehyde), since an inhibitor of catalase is able to completely prevent ethanol’s actions on VTA dopamine neuronal firing activity (Melis et al., 2007). 0000010350 00000 n
Acetaldehyde ��o���*�Z����|p���6��F��̱9~�;�7������q�Y ��"m�Ee �TE�� ����e�D�}!/iT���!o���\W0�:���K}���k�˶�zȄ?f����PgP���]:�!�2��ڌbkqVļΤN_�R:g�}�������[��G�Ӵ�8::���f҆�掽f��g>-'� 0000007008 00000 n
acetaldehyde + NADH + H + ethanol + NAD + In the reaction shown above: NADH is oxidized to NAD+ acetaldehyde is reduced to ethanol acetaldehyde is the oxidizing agent 7.014 Redox Handout 1 . Figure 1 Schematic representation of the metabolism of ethanol (ETOH) and the effects of aldehyde dehydrogenase (ALDH) inhibitors and catalase modulators.
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